5 Way Repel-and-Kill Pest Protection. K9 Advantix combines imidacloprid and permethrin to repel and kill ticks, fleas, and mosquitoes that may cross your dog path. Each ingredient begins to affect pests through contact, attacking parasite nerve cells at different sIt is. When combined, the two compounds overwhelm the parasite's nervous system. This leads to rapid paralysis and death of the parasite. Prevents ticks from attaching; stops biting fleas; repels mosquitoes; treats chewing lice.No need to reapply after a bath or weekly swimming; K9 Advantix is water,roof. Studies have shown your dog will still be protected after exposure to water,whether your dog has gone for a swim, has been given a bath or has been in the rain. For best results, dogs treated with K9 Advantix should be bathed with a non-detergent shampoo.